In recent years there is significant interest in using biodegradable polymeric microspheres for drug delivery. Delivering drugs through biodegradable microspheres has numerous advantages compared to conventional delivery systems. While in conventional systems the drug is usually released shortly after delivery and stops working after a brief period of time, biodegradable polymer offers a way to provide sustained release over…
Spray drying has been used in the production of fine powders from emulsions for many years, but it is not a process in which most people associate the production of microspheres. This journal article shows how the authors were able to produce highly spherical microspheres in the 1-10um range by controlling the levels of Chitosan and crosslinking agents…
During some research on PLGA microspheres we found this interesting article published in European Cells and Materials Vol 7 Suppl 2. 2004 (pages 11-12). They were able to achieve a significant change in the zeta potential of their microspheres just by increasing the dosage of Chitosan. The authors conclusions and a graph of their data…
One of the microsphere topics that seems to be growing these days is biodegradability. For those of you who are unfamiliar with the topic an excellent introductory article can be found in: Advance Drug Delivery Reviews 52 (2001) 5-16, called “Biodegradable microspheres for vitreoretinal drug delivery.” The article does a good job describing the advantages of the…